Toxicity

Toxicity Testing in the 21st Century: A Vision and a Strategy

Daniel Krewski, Daniel Acosta, Melvin E. Andersen, Henry A. Anderson, John C. Bailar, Kim Boekelheide, Robert J. Brent, Gail Charnley, Vivian G. Cheung, Sídney Green, Karl T. Kelsey, Nancy I. Kerkvliet, Abby A. Li, Lawrence McCray, Otto Meyer, Reid D. Patterson, William D. Pennie, Robert A. Scala, Gina Solomon, Martin L. Stephens, James D. Yager, Lauren Zeise, Staff of Committee on Toxicity Test

Citations: 1675 • 2010

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Anna Herland, Ben M. Maoz, Debarun Das, Mahadevabharath R. Somayaji, Rachelle Prantil‐Baun, Richard Novák, Michael J. Cronce, Tessa Huffstater, Sauveur S. F. Jeanty, Angeliki Chalkiadaki, David B. Chou, Susan Marquez, Aaron Delahanty, Sasan Jalili‐Firoozinezhad, Yuka Milton, Alexandra Sontheimer-Phelps, Ben Swenor, Oren Levy, Kevin Kit Parker, Andrzej Przekwas, Donald E. Ingber

Citations: 463 • 2020

Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests

Paweł Szymański, Magdalena Markowicz-Piasecka, Elżbieta Mikiciuk‐Olasik

Citations: 439 • 2011

Toxicity Testing in the 21st Century: Bringing the Vision to Life

Melvin E. Andersen, Daniel Krewski

Citations: 326 • 2008

Robotic Image-Guided Stereotactic Radiotherapy, for Isolated Recurrent Primary, Lymph Node or Metastatic Prostate Cancer

Barbara Alicja Jereczek‐Fossa, G. Beltramo, Laura Fariselli, Cristiana Fodor, Luigi Santoro, Andrea Vavassori, Dario Zerini, Federica Gherardi, Carmen Ascione, Isa Bossi-Zanetti, R. Di Mauro, Achille Bregantin, Livia Bianchi, Ottavio De Cobelli, Roberto Orecchia

Citations: 233 • 2011

A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®

Kristin M. Bircsak, Richard DeBiasio, Mark T. Miedel, Alaa Alsebahi, Ryan M. Reddinger, Anthony D. Saleh, Tongying Shun, Lawrence A. Vernetti, Albert Gough

Citations: 176 • 2021

A single-center study of 100 consecutive patients with localized prostate cancer treated with stereotactic body radiotherapy

Giampaolo Bolzicco, Maria Silvia Favretto, N Satariano, E. Scremin, C. Tambone, A. Tasca

Citations: 106 • 2013

Image-Guided Robotic Stereotactic Body Radiation Therapy for Liver Metastases: Is There a Dose Response Relationship?

C. Vautravers-Dewas, S. Dewas, F. Bonodeau, Antoine Adenis, T. Lacornerie, Nicolas Penel, Éric Lartigau, X. Mirabel

Citations: 89 • 2011

<i>In vivo</i>zebrafish assays for analyzing drug toxicity

Demetrio Raldúa, Benjamı́n Piña

Citations: 86 • 2014

Baseline Toxicity and Volatility Cutoff in Reporter Gene Assays Used for High-Throughput Screening

Beate I. Escher, Lisa Glauch, Maria König, Philipp Mayer, Rita Schlichting

Citations: 84 • 2019

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

Muhammad Umair, Ibrahim Javed, Mubashar Rehman, Asadullah Madni, Aqeel Javeed, Aamir Ghafoor, Muhammad Ashraf

Citations: 75 • 2016

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

Steven M. Bryce, Derek T. Bernacki, Jeffrey C. Bemis, Richard A. Spellman, Maria Engel, Maik Schuler, Elisabeth Lorge, Pekka T. Heikkinen, Ulrike Hemmann, Véronique Thybaud, Sabrina Wilde, Nina Queisser, Andreas Sutter, Andreas Zeller, Melanie Guérard, David Kirkland, Stephen D. Dertinger

Citations: 74 • 2017

Stereotactic radiotherapy of pancreatic cancer: a systematic review on pain relief

Milly Buwenge, Gabriella Macchia, A. Arcelli, R. Frakulli, Lorenzo Fuccio, Sara Guerri, Elisa Grassi, S. Cammelli, Francesco Cellini, A.G. Morganti

Citations: 64 • 2018

Fractionated stereotactic radiosurgery with concurrent temozolomide chemotherapy for locally recurrent glioblastoma multiforme: a prospective cohort study

Jeffrey Greenspoon, Waseem Sharieff, Holger W. Hirte, Andrew C. Overholt, Rocco DeVillers, Þorsteinn Gunnarsson, Anthony Whitton

Citations: 56 • 2014

Robotic system-based fractionated stereotactic radiotherapy in locally recurrent nasopharyngeal carcinoma

Young-Seok Seo, HyungJun Yoo, SungYul Yoo, Chul-Koo Cho, Kwangmo Yang, Mi‐Sook Kim, Chul Won Choi, YoungJu Shin, Dong‐Han Lee, GukHang Lee

Citations: 55 • 2009

Assessment of novel tobacco heating product THP1.0. Part 6: A comparative in vitro study using contemporary screening approaches

Mark Taylor, David Thorne, Tony Carr, Damien Breheny, Paul Walker, Christopher Proctor, Marianna Gaça

Citations: 54 • 2017

High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions

Caitlin Lynch, Srilatha Sakamuru, Masato Ooka, Ruili Huang, Carleen Klumpp‐Thomas, Paul Shinn, David Gerhold, Anna Rossoshek, Sam Michael, Warren Casey, Michael F. Santillo, Suzanne Fitzpatrick, Russell S. Thomas, Anton Simeonov, Menghang Xia

Citations: 49 • 2023

Brachytherapy-emulating robotic radiosurgery in patients with cervical carcinoma

Simone Marnitz, Christhardt Köhler, Volker Budach, Oliver Neumann, Anne Kluge, Waldemar Wlodarczyk, Ulrich Jahn, Bernhard Gebauer, Markus Kufeld

Citations: 48 • 2013

Robotic Stereotactic Radiosurgery in Melanoma Patients with Brain Metastases under Simultaneous Anti-PD-1 Treatment

Maike Trommer, Simone Marnitz, Martin Köcher, Daniel Rueß, Max Schlaak, Sebastian Theurich, Michael von Bergwelt‐Baildon, Janis Morgenthaler, Karolina Jabłońska, Eren Celik, Maximilian I. Ruge, Christian Baues

Citations: 45 • 2018

A Phase 1 Dose-Escalation Study of Robotic Radiosurgery in Inoperable Primary Renal Cell Carcinoma

Sean M. McBride, Andrew A. Wagner, I.D. Kaplan

Citations: 43 • 2013