Metabolite

Manual and automated (robotic) high-performance liquid chromatography methods for the determination of mycophenolic acid and its glucuronide conjugate in human plasma

Tsina Irene, Chu Frances, Kyle Hama, Martin Kaloostian, Ling Tam Yuen, Thomas Tarnowski, Wong Belinda

Citations: 115 • 1996

Metabolomic profiling in tomato reveals diel compositional changes in fruit affected by source–sink relationships

Camille Bénard, Stéphane Bernillon, Benoît Biais, Sonia Osorio, Mickaël Maucourt, Patricia Ballias, Catherine Deborde, Sophie Colombié, Cécile Cabasson, Daniel Jacob, Gilles Vercambre, Hélène Gautier, Dominique D. Rolin, Michel Génard, Alisdair R. Fernie, Yves Gibon, Annick Moing

Citations: 88 • 2015

Determination of the enantiomers of salbutamol and its 4-O-sulphate metabolites in biological matrices by chiral liquid chromatography tandem mass spectrometry

Karina B. Joyce, Anne E. Jones, Rebecca J. Scott, Robert Biddlecombe, Stephen Pleasance

Citations: 86 • 1998

Enantiomeric determination of tramadol and its main metabolite O-desmethyltramadol in human plasma by liquid chromatography–tandem mass spectrometry

Attilio Ceccato, Francis Vanderbist, J.-Y Pabst, Bruno Streel

Citations: 82 • 2000

Spectral trees as a robust annotation tool in LC–MS based metabolomics

Justin J. J. van der Hooft, Jacques Vervoort, R.J. Bino, Ric C. H. de Vos

Citations: 75 • 2011

Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection

John E. Coutant, Patricia A. Westmark, Pasqua Nardella, Silke Walter, Richard A. Okerholm

Citations: 72 • 1991

Fully Automated Trimethylsilyl (TMS) Derivatisation Protocol for Metabolite Profiling by GC-MS

Erica Zarate, Veronica Boyle, Udo Rupprecht, Saras Green, Silas G. Villas‐Bôas, Philip N. Baker, Farhana R. Pinu

Citations: 68 • 2016

Introduction to early in vitro identification of metabolites of new chemical entities in drug discovery and development.

Paweł Baranczewski, Andrzej Stańczak, Antti Kautiainen, Per Sandin, Per‐Olof Edlund

Citations: 63 • 2006

Assay method for the carboxylic acid metabolite of clopidogrel in human plasma by gas chromatography–mass spectrometry

P. Lagorce, Yolanda Pérez, Jordí Ortiz, Joseph Necciari, Françoise Bressolle

Citations: 62 • 1998

Quantitation of SU11248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid–liquid extraction

Simona Barattè, S. Sarati, E. Frigerio, Christopher James, Chuqi Ye, Qihui Zhang

Citations: 60 • 2003

Eliminating the dication-induced intersample chemical-shift variations for NMR-based biofluid metabonomic analysis

Limiao Jiang, Jing Huang, Yulan Wang, Huiru Tang

Citations: 58 • 2012

A high-throughput U-HPLC–MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine

Jacek Klepacki, Jelena Klawitter, Jamie Bendrick‐Peart, Björn Schniedewind, Svenja Heischmann, Touraj Shokati, Uwe Christians, Jost Klawitter

Citations: 49 • 2011

Rapid determination of the anti-cancer drug chlorambucil (Leukeran™) and its phenyl acetic acid mustard metabolite in human serum and plasma by automated solid-phase extraction and liquid chromatography–tandem mass spectrometry

Ieuan Davies, Jane Allanson, Roger C. Causon

Citations: 49 • 1999

Metabolite Characterization in Drug Discovery Utilizing Robotic Liquid- Handling, Quadruple Time-of-Flight Mass Spectrometry and In-Silico Prediction

Bentham Science Publisher A-E.F. Nassar, Paul D. Adams

Citations: 47 • 2003

Screening and quantitative determination of drugs of abuse in diluted urine by UPLC–MS/MS

Solfrid Hegstad, Sigurd Hermansson, Ingvar Betnér, Olav Spigset, Berit Margrethe Hasle Falch

Citations: 46 • 2013

Development of a high-throughput method for the determination of itraconazole and its hydroxy metabolite in human plasma, employing automated liquid–liquid extraction based on 96-well format plates and LC/MS/MS

Constantinos Kousoulos, Georgia Tsatsou, Constantinos Apostolou, Yannis Dotsikas, Yannis L. Loukas

Citations: 44 • 2005

Screening, quantification, and confirmation of synthetic cannabinoid metabolites in urine by UHPLC–QTOF–MS

Per Ole M. Gundersen, Olav Spigset, Martin Josefsson

Citations: 38 • 2018

Development and validation of an automated liquid-liquid extraction GC/MS method for the determination of THC, 11-OH-THC, and free THC-carboxylic acid (THC-COOH) from blood serum

Kirsten Purschke, Sonja Heinl, Oliver Lerch, Freidoon Erdmann, Florian Veit

Citations: 35 • 2016

Fully automated assay for the determination of sumatriptan in human serum using solid-phase extraction and high-performance liquid chromatography with electrochemical detection

Moira Dunne, Peter D. Andrew

Citations: 35 • 1996

Simultaneous screening and detection of drugs in small blood samples and bloodstains

Harald Schütz, Jan Christoph Gotta, Freidoon Erdmann, M. Riße, Günter Weiler

Citations: 34 • 2002