Drug

Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data

Alexander Aliper, Sergey Plis, Artem V. Artemov, Alvaro Ulloa, Polina Mamoshina, Alex Zhavoronkov

Citations: 600 • 2016

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Anna Herland, Ben M. Maoz, Debarun Das, Mahadevabharath R. Somayaji, Rachelle Prantil‐Baun, Richard Novák, Michael J. Cronce, Tessa Huffstater, Sauveur S. F. Jeanty, Angeliki Chalkiadaki, David B. Chou, Susan Marquez, Aaron Delahanty, Sasan Jalili‐Firoozinezhad, Yuka Milton, Alexandra Sontheimer-Phelps, Ben Swenor, Oren Levy, Kevin Kit Parker, Andrzej Przekwas, Donald E. Ingber

Citations: 463 • 2020

Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests

Paweł Szymański, Magdalena Markowicz-Piasecka, Elżbieta Mikiciuk‐Olasik

Citations: 439 • 2011

Enzyme-powered Janus platelet cell robots for active and targeted drug delivery

Songsong Tang, Fangyu Zhang, Hua Gong, Fanan Wei, Jia Zhuang, Emil Karshalev, Berta Esteban‐Fernández de Ávila, Chuying Huang, Zhidong Zhou, Zhengxing Li, Lu Yin, Haifeng Dong, Ronnie H. Fang, Xueji Zhang, Liangfang Zhang, Joseph Wang

Citations: 413 • 2020

Plant natural products: Back to the future or into extinction?

James D. McChesney, Sylesh K. Venkataraman, John T. Henri

Citations: 376 • 2007

Zebrafish embryos and larvae: A new generation of disease models and drug screens

Shaukat Ali, Danielle L. Champagne, Herman P. Spaink, Michael K. Richardson

Citations: 253 • 2011

The fluorometric microculture cytotoxicity assay

Elin Lindhagen, Peter Nygren, Rolf Larsson

Citations: 236 • 2008

The Next Era: Deep Learning in Pharmaceutical Research

Sean Ekins

Citations: 236 • 2016

Virtual Screening in Drug Discovery

Juan Alvarez, Brian K. Shoichet

Citations: 234 • 2005

Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood–brain barrier in vitro

Helmut Franke, Hans‐Joachim Galla, Carsten T. Beuckmann

Citations: 228 • 2000

Metabolic Stability for Drug Discovery and Development

Collen Masimirembwa, Ulf Bredberg, Tommy B. Andersson

Citations: 219 • 2003

Two approaches to discovering and developing new drugs for Chagas disease

McKerrow Jh, PS Doyle, Engel Jc, LM Podust, Sheilah A. Robertson, Rafaela Salgado Ferreira, T Saxton, Michelle R. Arkin, ID Kerr, LS Brinen, CS Craik

Citations: 173 • 2009

Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases

Kevin Williams, Elizabeth Bilsland, Andrew C. Sparkes, Wayne Aubrey, Michael J. Young, Larisa Soldatova, Kurt De Grave, Jan Ramon, Michaela de Clare, Worachart Sirawaraporn, Stephen G. Oliver, Ross D. King

Citations: 161 • 2015

Therapeutic drug monitoring and LC–MS/MS

Jo Adaway, Brian Keevil

Citations: 157 • 2011

Optimization of a Higher Throughput Microsomal Stability Screening Assay for Profiling Drug Discovery Candidates

Li Di, Edward H. Kerns, Yan Hong, Teresa Kleintop, Oliver J. McConnell, Donna M. Huryn

Citations: 137 • 2003

RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract

Shriya S. Srinivasan, Amro Alshareef, Alexandria Hwang, Ziliang Kang, Johannes Kuosmanen, Keiko Ishida, J. A. Jenkins, Sabrina Liu, Wiam Abdalla Mohammed Madani, Jochen K. Lennerz, Alison Hayward, Joshua Morimoto, Nina Fitzgerald, Róbert Langer, Giovanni Traverso

Citations: 114 • 2022

Zika Virus Protease: An Antiviral Drug Target

CongBao Kang, Thomas H. Keller, Dahai Luo

Citations: 103 • 2017

Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus

Rajmohan Rajamuthiah, Beth Burgwyn Fuchs, Elamparithi Jayamani, Younghoon Kim, Jonah Larkins‐Ford, Annie L. Conery, Frederick M. Ausubel, Eleftherios Mylonakis

Citations: 99 • 2014

A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects

Arvinder K. Dhalla, ZIAD T. AL-SHAMSIE, Simret Beraki, Anvesh Dasari, Leonard C. Fung, Laura Fusaro, Anusha Garapaty, Betsy Gutierrez, Delia Gratta, Mir A. Hashim, Kyle Horlen, Padma Karamchedu, Radhika Korupolu, Eric Liang, Chang Ong, Zachary Owyang, Vasudha Salgotra, Shilpy Sharma, Baber Syed, Mansoor Ali Syed, April Toledo Vo, Radia Abdul‐Wahab, Asad Wasi, Alyson Yamaguchi, Shane Yen, Mir Imran

Citations: 94 • 2021

Micro-scaffold array chip for upgrading cell-based high-throughput drug testing to 3D using benchtop equipment

Xiaokang Li, Xinyong Zhang, Shan Zhao, Jingyu Wang, Gang Liu, Yanan Du

Citations: 94 • 2013