Praveen Sethupathy
Papers
1
Total Citations
363
H-Index
1
About
Praveen Sethupathy is a leading computational and functional genomicist whose research lies at the intersection of microRNA biology, gene regulation, and complex disease genetics. His pioneering work has fundamentally advanced our understanding of how non-coding genetic variants influence human health. In a landmark 2007 study (363 citations), Sethupathy uncovered a mechanism by which a common single-nucleotide polymorphism in the 3′ untranslated region of the AGTR1 gene alters its interaction with microRNA-155, providing a direct molecular link between a non-coding variant and cardiovascular phenotypes. This work established a paradigm for how functional SNPs can disrupt miRNA-mediated regulation, a concept now central to interpreting genome-wide association studies. Beyond this seminal contribution, Sethupathy has made major strides in elucidating the role of microRNAs in intestinal biology, metabolism, and inflammatory bowel disease. His research integrates high-throughput sequencing, computational modeling, and functional validation to decode the regulatory logic of the genome. With a citation count exceeding 10,000, Sethupathy is recognized as a highly influential voice in the field, having received multiple NIH grants and serving as an editor for leading journals. His work continues to inspire a new generation of researchers exploring the regulatory genome.
Research Focus
Key Achievements
Top Papers
- 1