Lars Van Eynde
Papers
2
Total Citations
32
H-Index
2
About
Lars Van Eynde is a medicinal chemist driving innovation in automated synthesis and purification for drug discovery. His research centers on developing high-throughput methodologies that accelerate the generation of complex molecules, with a particular focus on enabling challenging carbon-carbon bond formations using abundant, diverse building blocks. Van Eynde’s most impactful work, "Enabling Deoxygenative C(sp²)-C(sp³) Cross-Coupling for Parallel Medicinal Chemistry" (2023, 26 citations), introduces an automated metallaphotoredox platform that transforms alcohols—among the most plentiful and varied alkyl precursors—into coupling partners for aryl bromides. This breakthrough overcomes a long-standing limitation in parallel medicinal chemistry, allowing researchers to rapidly explore chemical space with readily available reagents. Complementing this, his work on "Automated high-throughput RP-HPLC-MS and SFC-MS analytical and purification platforms" (2024, 6 citations) provides the critical infrastructure to support such high-speed synthesis. By integrating reaction development with automated purification, Van Eynde is helping to redefine the pace and scope of medicinal chemistry, offering tools that promise to shorten the cycle from design to candidate selection.
Research Focus
Key Achievements
Top Papers
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