Stefaan Last
Papers
1
Total Citations
26
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1
About
Dr. Stefaan Last is a leading figure in the development of automated, high-throughput synthetic methodologies for medicinal chemistry. His research centers on enabling challenging carbon-carbon bond formations, particularly deoxygenative cross-coupling reactions that transform abundant alcohols into valuable alkyl fragments. In his highly cited 2023 work (26 citations), Dr. Last reported a breakthrough automated metallaphotoredox protocol for C(sp²)-C(sp³) coupling of aryl bromides with alcohols. This innovation directly addresses a critical bottleneck in parallel medicinal chemistry: the limited use of alcohols as alkyl precursors due to their poor leaving group ability. By rendering this transformation robust and automatable, his work dramatically expands the accessible chemical space for drug discovery, allowing researchers to rapidly generate diverse compound libraries from simple, commercially available building blocks. Dr. Last’s contributions are pivotal for accelerating the synthesis of novel therapeutics, bridging the gap between fundamental photoredox catalysis and practical, industrial-scale parallel synthesis.
Research Focus
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