Lars Barquist

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About

Lars Barquist is a leading researcher in bacterial transcriptomics and RNA biology, whose work has fundamentally advanced our understanding of gene regulation in bacteria. His key research areas include single-cell RNA sequencing, bacterial small RNAs, and host-pathogen interactions. Barquist’s major contribution is the development of MATQ-seq, a groundbreaking method for transcriptomic profiling of individual bacteria, which was published in 2025 and has already garnered 8 citations, highlighting its rapid impact on the field. This technique enables unprecedented resolution of bacterial gene expression heterogeneity, opening new avenues for studying antibiotic resistance, persistence, and infection dynamics. Beyond this, Barquist has made notable contributions to the discovery and functional characterization of small regulatory RNAs in pathogens like Salmonella, using high-throughput approaches such as RNA-seq and CLASH. His work has been recognized with early-career awards and is widely cited for its methodological innovation and biological insights. For students and researchers, Barquist’s research exemplifies how cutting-edge single-cell technologies can transform our understanding of bacterial behavior at the individual cell level, with profound implications for microbiology and infectious disease.