Jessica Lukowski

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About

Dr. Jessica Lukowski is a leading figure in the emerging field of spatial metabolomics, where her work has fundamentally advanced how researchers visualize and analyze molecular landscapes directly within biological tissues. Her primary contributions center on refining mass spectrometry imaging (MSI) protocols, enabling the simultaneous detection of hundreds of metabolites, lipids, and peptides from single cells and intact organs. Her highly cited protocol, "Tissue Preparation for Spatial Metabolomics v1," has become a foundational resource for laboratories worldwide, providing a standardized method for preparing flash-frozen tissue cryosections on conductive slides—a critical step for achieving high-resolution molecular maps. Though a relatively early-career researcher, Lukowski’s methodological innovations have already garnered significant attention, with her work cited over 100 times collectively. She is particularly recognized for bridging the gap between complex analytical chemistry and practical biomedical applications, making spatial metabolomics more accessible to biologists and clinicians. Her achievements include developing workflows that preserve both spatial integrity and molecular fidelity, a breakthrough that has opened new avenues for studying cancer heterogeneity, neurodegenerative disease, and drug distribution at the cellular level. Dr. Lukowski’s research continues to push the boundaries of how we see metabolism in space and time.