Dineika Chandrananda
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1
Total Citations
109
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1
About
Dineika Chandrananda is a leading researcher in the field of liquid biopsy and cancer genomics, with a primary focus on the pre-analytical variables that govern circulating cell-free DNA (cfDNA) analysis. Her seminal work, "Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients" (2018, 109 citations), has become a cornerstone reference for the field. In this study, Chandrananda systematically demonstrated how common collection and processing protocols can inadvertently elevate cfDNA levels through leukocyte lysis, thereby diluting the critical signal from circulating tumor DNA (ctDNA). By identifying these confounding factors, she provided essential guidelines for standardizing pre-analytical workflows, directly improving the sensitivity and reproducibility of liquid biopsy assays. Her contributions are vital for translating ctDNA detection from research into robust clinical tools for noninvasive cancer management. Chandrananda’s work continues to shape best practices in oncology diagnostics, ensuring that the promise of liquid biopsies is realized through rigorous, reproducible methodology.
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