Davina Gale
Papers
1
Total Citations
109
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1
About
Davina Gale is a leading translational researcher whose work centers on the pre-analytical and methodological challenges of liquid biopsy, with a particular focus on circulating tumor DNA (ctDNA) for noninvasive cancer management. Her major contribution lies in systematically identifying how blood collection and processing procedures critically impact the detection of ctDNA, which often constitutes only a minor fraction of total cell-free DNA (cfDNA). Her landmark 2018 study, cited over 100 times, demonstrated that pre-analytical factors—such as tube type, storage time, and centrifugation protocols—can artificially inflate cfDNA levels through leukocyte lysis, thereby masking the true tumor-derived signal. This work has become a foundational reference for standardizing liquid biopsy protocols in both research and clinical settings. Gale’s rigorous approach has helped establish best practices that improve the sensitivity and reproducibility of ctDNA assays, directly enabling more reliable noninvasive cancer monitoring. Her research is essential reading for any student or researcher working in liquid biopsy, precision oncology, or circulating nucleic acid diagnostics.
Research Focus
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Top Papers
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