Biopharmaceutical
Related papers: 20
About
Biopharmaceuticals are medical drugs produced through biotechnology, typically involving living organisms such as cells, bacteria, or yeast to create therapeutic proteins, antibodies, vaccines, and gene therapies. Unlike traditional small-molecule drugs synthesized chemically, biopharmaceuticals are large, complex molecules that require precise biological manufacturing processes. In robotics and AI, biopharmaceutical development leverages automation for high-throughput screening, cell line development, purification, and quality control. Robotic systems handle repetitive tasks like liquid handling, sample preparation, and chromatography, while AI algorithms analyze complex data from mass spectrometry, spectroscopy, and glycomics to optimize yields, ensure consistency, and accelerate drug discovery. Automation reduces human error, increases throughput, and enables real-time monitoring of critical quality attributes. This matters because biopharmaceuticals are vital for treating cancers, autoimmune diseases, and infectious diseases, yet their production is costly and time-sensitive. Integrating robotics and AI streamlines manufacturing, lowers costs, improves product quality, and speeds up delivery of life-saving therapies to patients.
Top Researchers
Henning Stöckmann
Institution: —
B Adamczyk
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Jerrard M. Hayes
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Pauline M. Rudd
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Karli R. Reiding
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Manfred Wuhrer
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Archana Shubhakar
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Richard A. Gardner
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Daniel I. R. Spencer
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Daryl L. Fernandes
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Top Institutes
Top Cited Papers
Automated, High-Throughput IgG-Antibody Glycoprofiling Platform
Henning Stöckmann, B Adamczyk, Jerrard M. Hayes, Pauline M. Rudd
Citations: 107 • 2013
High-Throughput Analysis and Automation for Glycomics Studies
Archana Shubhakar, Karli R. Reiding, Richard A. Gardner, Daniel I. R. Spencer, Daryl L. Fernandes, Manfred Wuhrer
Citations: 83 • 2014
Automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS
Archana Shubhakar, Radoslaw P. Kozak, Karli R. Reiding, Louise Royle, Daniel I. R. Spencer, Daryl L. Fernandes, Manfred Wuhrer
Citations: 78 • 2016
Streamlining bioactive molecular discovery through integration and automation
Shiao Y. Chow, Samuel Liver, Adam Nelson
Citations: 50 • 2018
Rapid N -glycan release from glycoproteins using immobilized PNGase F microcolumns
Márton Szigeti, Judit Bondar, Douglas T. Gjerde, Zsolt Keresztessy, Ákos Szekrényes, András Guttman
Citations: 47 • 2016
Automation of cell line development
Kristina Lindgren, Andrea Salmén, Mats Lundgren, Lovisa Bylund, Åsa Ebler, Eric Fäldt, Lina Sörvik, Christel Fenge, Ulrica Skoging-Nyberg
Citations: 47 • 2009
Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies
Daniel J. Scott, Lutz Kummer, Pascal Egloff, Ross A. D. Bathgate, Andreas Plückthun
Citations: 39 • 2014
Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort
Alex J. Spice, Rochelle Aw, Daniel G. Bracewell, Karen M. Polizzi
Citations: 33 • 2020
In-line product quality monitoring during biopharmaceutical manufacturing using computational Raman spectroscopy
Jiarui Wang, Jingyi Chen, Joey Studts, Gang Wang
Citations: 27 • 2023
Recent developments of automated flow chemistry in pharmaceutical compounds synthesis
Jiashu Wu, Xingxing Yang, Yourong Pan, Tao Zuo, Zuozhou Ning, Chengxi Li, Zhiguo Zhang
Citations: 24 • 2023
An automated packed Protein G micro-pipette tip assay for rapid quantification of polyclonal antibodies in ovine serum
Sunil Chhatre, Richard Francis, Daniel G. Bracewell, Nigel J. Titchener‐Hooker
Citations: 21 • 2010
A fully automated three-step protein purification procedure for up to five samples using the NGC chromatography system
Wolfgang Becker, Anne Scherer, Christine Faust, David Kornblüh Bauer, Simone Scholtes, Ercole Rao, Joachim Hofmann, Rolf Schauder, Thomas Langer
Citations: 18 • 2018
Development of an Automated, High-Throughput Methodology for Native Mass Spectrometry and Collision-Induced Unfolding
Brock Juliano, Joseph W. Keating, Henry W. Li, Anna G. Anders, Zhuoer Xie, Brandon T. Ruotolo
Citations: 15 • 2023
Recent Industrial Roadmaps to Enable Smart Manufacturing of Biopharmaceuticals
Sheng Lin‐Gibson, Vijay Srinivasan
Citations: 14 • 2019
UV-absorbance, fluorescence and FT-IR spectroscopy in biopharmaceutical development
Mark L. Brader
Citations: 12 • 2019
Characterization and Reverse Engineering of Pharmaceuticals: Role of Thermoanalytical Techniques
Gobardhan Bal, K Vijaya Lakshmi, M. Rajkumar, Bibhash Chandra Mohanta
Citations: 6 • 2023
Progress in Bioanalytics and Automation Robotics for Absorption, Distribution, Metabolism, and Excretion Screening
J. Wang, B. Faller
Citations: 5 • 2007
Automation of Immunoglobulin Glycosylation Analysis
Jenifer L. Hendel, Richard A. Gardner, Daniel I. R. Spencer
Citations: 3 • 2021
An automated, low volume, and high-throughput analytical platform for aggregate quantitation from cell culture media
Giulia Lambiase, Kerensa Klottrup‐Rees, Clare Lovelady, Salma Ali, Samuel Shepherd, Maurizio Muroni, Viv Lindo, David C. James, Mark J. Dickman
Citations: 3 • 2023
Chapter 5 In vitro dmpk screening in drug discovery, role of lc-ms/ms
Inhou Chu, Amin A. Nomeir
Citations: 3 • 2005