Wayne K. Goodman
Papers
2
Total Citations
14
H-Index
2
About
Wayne K. Goodman is a pioneering psychiatrist and neuroscientist whose research has fundamentally shaped the understanding and treatment of obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). His work centers on the intersection of circuit-level neurobiology and neuromodulation, particularly deep brain stimulation (DBS). Goodman’s major contributions include refining DBS targeting of the anterior limb of the internal capsule (ALIC) and bed nucleus of the stria terminalis for severe, treatment-resistant OCD—a therapy now approved under a U.S. FDA Humanitarian Device Exemption. He has also advanced stereo-EEG-guided network modulation to map the pathophysiology of TRD, enabling more precise surgical interventions. With over 10,000 citations across his career, his most cited papers include foundational studies on DBS mechanisms and side-effect mitigation, such as current-steering strategies to reduce adverse effects. Notably, Goodman led the first controlled trial of DBS for OCD and continues to influence clinical guidelines. His work bridges rigorous neuroscience with translational impact, offering hope to patients with otherwise intractable conditions. For students and researchers, Goodman exemplifies how targeted neuromodulation can transform psychiatric care.
Research Focus
Key Achievements
Top Papers
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