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About

Nicole R. Provenza is a leading researcher at the intersection of neurosurgery, psychiatry, and bioengineering, whose work is redefining how we understand and treat severe psychiatric disorders through advanced neuromodulation. Her primary research areas focus on deep brain stimulation (DBS) and stereo-electroencephalography (SEEG) for conditions like treatment-resistant depression (TRD) and obsessive-compulsive disorder (OCD). A key contribution is her pioneering use of SEEG to map the neural circuits underlying psychiatric illness, enabling more precise, network-based surgical targeting. She has also advanced DBS therapy by demonstrating how current-steering strategies can attenuate side effects in the bed nucleus of the stria terminalis for OCD, improving patient tolerability. Her work on "Stereo-EEG-guided network modulation for psychiatric disorders" (2023, 10 citations) and "Attenuating side effects of deep brain stimulation...using current-steering strategies" (2023, 4 citations) highlights her commitment to translating cutting-edge engineering into clinical practice. Provenza’s research is instrumental in moving psychiatric neurosurgery from a one-size-fits-all approach toward personalized, circuit-specific interventions, offering new hope for patients with otherwise intractable conditions.