Tatsuji Matsuoka
Papers
1
Total Citations
14
H-Index
1
About
Dr. Tatsuji Matsuoka is a pioneering researcher in microbial fermentation and the biotechnological production of high-value amino acids. His key research areas include microbial screening, chiral synthesis, and the industrial application of fungal metabolites. Dr. Matsuoka’s most notable contribution is the fermentative production of *trans*-4-hydroxy-L-proline, a critical chiral building block for the side chain of carbapenem antibiotics. In his landmark 1995 study, he employed an innovative automated screening-robot system (AminoQuant) to evaluate thousands of microorganisms, identifying a strain of *Clonostachys cylindrospora* capable of producing 13.8 μg/mL of the target compound. This work, cited 14 times, laid the groundwork for sustainable, fermentation-based alternatives to chemical synthesis of pharmaceutical intermediates. By bridging microbiology and medicinal chemistry, Dr. Matsuoka’s research has advanced the efficient production of complex chiral molecules, offering a greener pathway for antibiotic development. His achievements highlight the power of automated high-throughput screening in discovering novel microbial capabilities, making his work a valuable reference for students and researchers in bioprocess engineering and natural product chemistry.
Research Focus
Key Achievements
Top Papers
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