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About

Dr. Sreenija Yarlagadda is a pioneering radiation oncologist whose research focuses on the application of advanced radiosurgery techniques for complex oncologic conditions, particularly in hepatocellular carcinoma (HCC) and brain metastases. Her most impactful work addresses the challenging scenario of HCC patients with portal vein tumor thrombosis (PVTT), where she has demonstrated the safety and efficacy of robotic radiosurgery. In a landmark prospective study (2021, 15 citations), she provided interim evidence that this non-invasive approach can achieve meaningful tumor response and improve survival outcomes in vascular-invasive HCC—a population often deemed inoperable. Dr. Yarlagadda further validated these findings in a 2024 study (2 citations) correlating PVTT response with survival functions. Additionally, she has made significant contributions to neuro-oncology through a large prospective evaluation (2023, 4 citations) of 138 Indian patients with oligo-brain metastases treated with stereotactic radiosurgery (SRS) alone, establishing treatment response patterns and toxicity profiles in this underrepresented population. Her work uniquely bridges the gap between advanced radiation technology and real-world clinical outcomes, offering hope for patients with traditionally poor-prognosis cancers. Dr. Yarlagadda’s research is characterized by rigorous prospective methodology and a focus on improving survival while minimizing treatment-related toxicity.