Shajna Begum
Papers
3
Total Citations
474
H-Index
3
About
Shajna Begum is a leading figure in redox proteomics, whose work has fundamentally advanced our understanding of how oxidative stress reshapes protein function in cardiovascular and musculoskeletal diseases. Her research centers on the detection and functional mapping of reversible cysteine modifications—particularly protein S-glutathiolation and intermolecular disulfide formation—that act as molecular switches during cellular stress. In her landmark 2004 study (188 citations), Begum pioneered the use of diagonal electrophoresis to reveal widespread protein disulfide bonding in cardiac tissue under oxidative load, establishing a critical framework for linking redox signaling to heart pathology. She further developed innovative tools, such as N,N-biotinyl glutathione disulfide (124 citations), to specifically trap and characterize S-glutathiolated proteins, enabling precise dissection of this protective yet pathogenic modification. Beyond the heart, Begum applied proteomics to osteoarthritis, demonstrating in a highly cited 2004 paper (162 citations) that articular cartilage exhibits increased type II collagen synthesis and secretes regulatory molecules like activin A, offering new insights into joint disease mechanisms. Her work has been instrumental in translating redox chemistry into biological context, earning her recognition as a pioneer in oxidative stress proteomics and a key contributor to the molecular understanding of cardiac and cartilage pathophysiology.
Research Focus
Key Achievements
Top Papers
- 1
- 2
- 3