Scott C. Lester
Papers
3
Total Citations
73
H-Index
3
About
Dr. Scott C. Lester is a radiation oncologist and clinical researcher whose work centers on de-escalation strategies for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). His major contributions include leading and analyzing landmark clinical trials—such as MC1675 and MC1273—that investigate whether reducing the intensity of adjuvant radiation therapy can maintain excellent oncologic outcomes while significantly lowering treatment-related toxicity. Dr. Lester’s research has been highly influential, with his most-cited paper, a Phase III evaluation of de-escalated adjuvant radiation (DART), accumulating over 50 citations. He has also advanced the understanding of postoperative circulating tumor HPV DNA (ctHPVDNA) kinetics, demonstrating its critical role as a biomarker for early detection of residual disease. Through his work on transoral robotic surgery outcomes and prospective de-escalation trials, Dr. Lester has helped shape a new paradigm in head and neck cancer care—one that prioritizes both cure and quality of life. His findings are essential reading for clinicians and researchers seeking to personalize treatment for HPV-positive OPSCC patients.
Research Focus
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Top Papers
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