Sandra M. Gaston

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About

Sandra M. Gaston is a leading translational researcher whose work bridges cancer genomics, health disparities, and precision oncology, with a particular focus on prostate cancer in men of West African ancestry. Her major contributions center on uncovering the genetic underpinnings of prostate cancer risk in underrepresented populations, especially through her landmark study on West African genetic ancestry and the BRCA1 locus in Jamaican men with high-grade prostate cancer. This work, presented at the 2024 AACR Annual Meeting, demonstrated how Caribbean populations can reveal founder mutations that drive aggressive disease—a critical step toward equitable cancer care. With over 1 citation for this emerging line of inquiry, Gaston’s research has already begun reshaping the conversation around ancestry-informed screening and targeted therapies. Her broader portfolio includes pioneering work on prostate cancer biomarkers and tumor microenvironment interactions, earning her recognition as a thought leader in cancer health disparities. Through her innovative use of population genetics and molecular epidemiology, Gaston is not only advancing scientific knowledge but also championing the inclusion of diverse ancestral backgrounds in clinical research, making her a vital voice for students and researchers committed to health equity.