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About

Ruben H.J. de Kleine is a leading surgical researcher whose work centers on minimally invasive pancreatic and hepatobiliary surgery, with a particular focus on oncological safety and complex congenital conditions. He is best known for his pivotal role in the DIPLOMA trial, an international randomised non-inferiority study comparing minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer. This landmark 2023 paper, with 121 citations, provided crucial evidence on the oncological safety of minimally invasive techniques, directly addressing long-standing concerns in the field. Dr. de Kleine has also made significant contributions to the surgical management of patients with Multiple Endocrine Neoplasia type 1 (MEN1), demonstrating the feasibility and benefits of robot-assisted spleen-preserving pancreatic surgery in this young, high-risk population. Additionally, his work extends to rare biliary anomalies, as seen in his report on robot-assisted resection of a Todani type II choledochal malformation. Through these contributions, Dr. de Kleine has advanced the evidence base for minimally invasive approaches, improving surgical outcomes and expanding treatment options for patients with complex pancreatic and biliary diseases.