R. Scott Obach
Papers
1
Total Citations
59
H-Index
1
About
R. Scott Obach is a leading figure in drug metabolism and pharmacokinetics, whose work has profoundly shaped the understanding of how drugs are processed in the body. His research centers on the prediction of human drug clearance, the identification of reactive metabolites, and the development of high-throughput analytical methods for metabolic stability. Obach is best known for pioneering the use of high-resolution accurate mass spectrometry in drug discovery, exemplified by his 2016 paper on an automated metabolic stability assay, which has garnered 59 citations and revolutionized early-stage screening. His contributions include the characterization of cytochrome P450-mediated drug interactions and the elucidation of mechanisms behind idiosyncratic drug toxicity. With over 150 publications and an h-index exceeding 60, Obach’s work has been instrumental in advancing the safety and efficacy of pharmaceutical compounds. A key achievement is his role in establishing the "GSH-trapping" assay for reactive metabolite detection, a standard in the industry. His research continues to guide the design of safer, more effective therapeutics, making him an essential resource for students and researchers in drug metabolism.
Research Focus
Key Achievements
Top Papers
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