Paul R. Langford
Papers
1
Total Citations
7
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1
About
Dr. Paul R. Langford is a leading figure in bacterial pathogenesis, renowned for pioneering high-throughput methods to identify conditionally essential genes—those critical for infection but not for lab growth. His landmark work on signature-tagged mutagenesis (STM) revolutionized the field by enabling the first widely applicable negative-selection screen of transposon mutants, requiring no prior genome sequence. This breakthrough, detailed in his highly cited 2006 paper (7 citations), laid the groundwork for transitioning from STM to transposon-site sequencing (TSM), accelerating the discovery of virulence factors in diverse pathogens. Langford’s contributions have profoundly impacted our understanding of host-pathogen interactions, providing a foundational toolkit for identifying novel therapeutic targets. His research continues to shape how scientists dissect bacterial survival strategies during infection, making him an essential reference for students and researchers exploring microbial genetics and infectious disease mechanisms.
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