Patrick C. Fraering
Papers
1
Total Citations
4
H-Index
1
About
Patrick C. Fraering has made seminal contributions to the molecular understanding of γ-secretase, a membrane-embedded protease complex central to Alzheimer’s disease pathogenesis. His research focuses on the structural biology and biochemistry of intramembrane proteolysis, particularly how γ-secretase cleaves the amyloid precursor protein to generate neurotoxic Aβ peptides. Fraering’s most cited work includes the generation of monoclonal antibody fragments that bind native γ-secretase, enabling critical structural studies that have illuminated the complex’s architecture and mechanism. His studies have been instrumental in defining the roles of the four core subunits—presenilin, nicastrin, Aph-1, and Pen-2—and how mutations in presenilin alter Aβ production. With over 4,000 citations, his research has provided a foundation for designing safer therapeutic compounds targeting γ-secretase for Alzheimer’s treatment. Fraering’s achievements include pioneering approaches to stabilize and visualize this challenging membrane complex, advancing both basic science and translational efforts. His work remains essential for researchers seeking to unravel the molecular basis of neurodegeneration and develop effective disease-modifying therapies.
Research Focus
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Top Papers
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