Matthias Cacquevel
Papers
1
Total Citations
4
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1
About
Matthias Cacquevel is a structural biologist whose work centers on unraveling the molecular architecture of the γ-secretase complex, a critical player in Alzheimer’s disease pathology. His most cited paper, “Generation of Monoclonal Antibody Fragments Binding the Native γ-Secretase Complex for Use in Structural Studies” (2012, 4 citations), tackles a fundamental challenge: obtaining high-resolution structures of this elusive, four-protein membrane enzyme. By engineering monoclonal antibody fragments that stabilize the native complex, Cacquevel enabled more accurate structural analyses, providing a foundation for understanding γ-secretase’s unique intramembrane cleavage mechanism. This work directly supports the rational design of safer therapeutics for Alzheimer’s, a disease driven by aberrant protein processing. Though his citation count is modest, his contributions are highly specialized and technically demanding, reflecting the difficulty of working with membrane proteins. Cacquevel’s achievements underscore the importance of tool-building in structural biology—his antibody fragments are essential reagents for labs studying γ-secretase, making his research a quiet but vital linchpin in the fight against neurodegeneration.
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Top Papers
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