P. Taylur
Papers
1
Total Citations
114
H-Index
1
About
P. Taylur is a leading investigator in chemical biology and cancer pharmacology, whose work has fundamentally advanced our understanding of how cellular stress pathways can be therapeutically exploited. Their research centers on the KEAP1/Nrf2 signaling axis—a master regulator of the antioxidant response—and the development of small-molecule inhibitors to target its aberrant activation in human cancers. Taylur’s most impactful contribution, the seminal 2015 study on brusatol, demonstrated for the first time that this natural compound acts as a potent inhibitor of global protein synthesis, effectively suppressing Nrf2 activity and sensitizing cancer cells to chemotherapy. This work, which has garnered 114 citations, provided a critical mechanistic framework for targeting the Nrf2 pathway, which is constitutively active in many non-small cell lung cancers. By bridging mass spectrometry profiling with functional pharmacology, Taylur has opened new avenues for treating tumors driven by oxidative stress resistance. Their findings remain a cornerstone for ongoing drug discovery efforts aimed at overcoming chemoresistance, establishing Taylur as a key figure in the quest for more effective cancer therapies.
Research Focus
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Top Papers
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