Papers
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Total Citations
6
H-Index
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About
Dr. Munjal Patel is a leading researcher in HIV eradication strategies, with a primary focus on latency reversal and pharmacokinetic/pharmacodynamic (PK/PD) modeling. Their most cited work, "In Vitro Pharmacokinetic/Pharmacodynamic Modeling of HIV Latency Reversal by Novel HDAC Inhibitors Using an Automated Platform" (2021, 6 citations), addresses a critical barrier to curing chronic HIV infection: the persistence of latently infected cells despite effective antiretroviral therapy. Dr. Patel’s major contribution lies in developing innovative, automated in vitro platforms to evaluate histone deacetylase inhibitors (HDACis) as latency-reversing agents. By integrating PK/PD modeling, they provide a quantitative framework to optimize drug dosing and predict in vivo efficacy, bridging the gap between preclinical testing and clinical application. This work has significant implications for designing more effective "shock and kill" therapies aimed at eradicating the HIV reservoir. Dr. Patel’s research is notable for its translational approach, combining cutting-edge automation with rigorous pharmacological analysis to tackle one of the most stubborn challenges in HIV cure research. Their findings offer a pathway toward reducing or eliminating the need for lifelong therapy, representing a meaningful step forward in the quest for an HIV cure.
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