Monika de Arruda
Papers
1
Total Citations
215
H-Index
1
About
Monika de Arruda has made foundational contributions to the field of high-throughput genomics, with a particular focus on the development and automation of single-nucleotide polymorphism (SNP) genotyping technologies. Her most cited work, "Evaluation of Single Nucleotide Polymorphism Typing with Invader on PCR Amplicons and Its Automation" (2000, 215 citations), established a robust framework for large-scale pharmacogenetics and complex disease association studies. In this landmark study, de Arruda demonstrated that the Invader assay, when applied to PCR amplicons, could achieve an accuracy exceeding 99% with a failure rate below 5%, all within a simple, reliable, and flexible automated platform. This work directly addressed the critical need for scalable genotyping systems capable of processing thousands of SNPs across thousands of individuals—a prerequisite for modern population-based genetic research. By validating a method that combined high precision with practical automation, de Arruda helped pave the way for subsequent advances in personalized medicine and genomic epidemiology. Her research remains a cornerstone reference for scientists developing cost-effective, high-fidelity genotyping pipelines, underscoring her lasting impact on the infrastructure of human genetics.
Research Focus
Key Achievements
Top Papers
- 1