Michael Kofler

Freie Universität Berlin, Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Papers

Total Citations

H-Index

About

Michael Kofler is a molecular biologist whose research centers on protein-protein interactions, particularly those mediated by GYF domains—conserved eukaryotic adaptor modules that recognize proline-rich sequences. His major contributions have significantly advanced our understanding of how these domains function as cellular adapters, bridging signaling and splicing machinery. In his seminal 2005 work, "GYF Domain Proteomics Reveals Interaction Sites in Known and Novel Target Proteins" (54 citations), Kofler systematically mapped the interactome of GYF domains beyond the well-studied human CD2BP2 protein, uncovering new binding partners and interaction sites that expanded the known functional landscape of these domains. His complementary study, "Novel Interaction Partners of the CD2BP2-GYF Domain" (27 citations), employed a general screening approach to identify previously unknown targets of the CD2BP2-GYF domain, moving beyond the established interactions with CD2 and SmB/B′. Together, these works established a robust proteomic framework for decoding GYF domain specificity, providing foundational tools for researchers studying adaptor-mediated signaling and splicing regulation. Kofler’s work remains a key reference for those investigating how modular protein domains orchestrate complex cellular networks.