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Meitian Wang is a leading figure in macromolecular crystallography, specializing in the development of innovative instrumentation and methodologies for structural biology. His key research areas include serial crystallography, membrane protein structure determination, and advanced diffractometer design. Wang’s major contributions center on revolutionizing data collection for challenging protein crystals. He pioneered the *in meso in situ* serial X-ray crystallography method (98 citations), which eliminates the need for delicate crystal harvesting by allowing data collection directly from the growth medium, a breakthrough for fragile membrane protein crystals. He also led the development of the PRIGo multi-axis goniometer (59 citations) and the D3 diffractometer (23 citations) for the Swiss Light Source, significantly enhancing sample reorientation and microcrystallography capabilities. More recently, his team introduced 3D-printed holders for fixed-target serial crystallography (13 citations), further streamlining high-throughput data collection. Wang’s work has profoundly impacted the field by making structural studies of previously intractable proteins more accessible, enabling researchers to obtain high-resolution structures with unprecedented efficiency.