Nicole Howe
Papers
1
Total Citations
98
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1
About
Nicole Howe is a structural biologist renowned for pioneering innovations in serial X-ray crystallography, with a particular focus on membrane proteins and cryogenic techniques. Her most influential work introduces an elegant method for *in meso in situ* serial crystallography, enabling diffraction data collection directly from crystals grown in lipid cubic or sponge phases at cryogenic temperatures. This breakthrough, detailed in her 2015 paper (98 citations), eliminates the technically demanding and inefficient crystal-harvesting step that has long been a bottleneck in structural studies of soluble and membrane proteins. By streamlining the process, Howe’s approach has significantly accelerated the determination of high-resolution structures, particularly for challenging membrane proteins that are critical targets in drug discovery. Her contributions have been widely adopted by the structural biology community, enhancing throughput and reducing sample consumption in synchrotron and X-ray free-electron laser experiments. Howe’s work exemplifies how methodological ingenuity can transform experimental workflows, making her a key figure in advancing the field of macromolecular crystallography. Her research continues to inspire new strategies for studying proteins in native-like environments.
Research Focus
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Top Papers
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