Masatsugu Horiuchi

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About

Masatsugu Horiuchi is a leading figure in cardiovascular and renal pathophysiology, with a particular focus on the renin-angiotensin system (RAS). His research has fundamentally reshaped our understanding of how angiotensin II receptors, specifically the type 2 receptor (AT2R), modulate inflammation and tissue injury. In his highly cited 2006 work, Horiuchi demonstrated a novel anti-inflammatory role for AT2R in immune-mediated glomerulonephritis during type 1 receptor blockade, a finding that challenged prevailing views and opened new therapeutic avenues for kidney disease. With over 40 citations, this paper exemplifies his ability to uncover protective mechanisms within the RAS. Beyond this, Horiuchi’s broader contributions—spanning hypertension, vascular remodeling, and organ protection—have earned him international recognition, including numerous awards and editorial roles. His work continues to inspire researchers exploring the dual, context-dependent actions of angiotensin receptors, bridging basic science and clinical translation.