Papers
20
Total Citations
773
H-Index
16
About
Dr. Manuela Costantini is a leading urologic surgeon and researcher whose work has fundamentally advanced the field of nephron-sparing surgery, particularly through the refinement of robotic partial nephrectomy. Her primary research focus is on eliminating renal ischemia during tumor resection, a pursuit that has led to the development and validation of innovative "off-clamp" techniques. Dr. Costantini’s seminal contributions include pioneering the use of controlled hypotensive anesthesia and indocyanine green fluorescence to safely perform off-clamp procedures, even for complex, totally endophytic, and large (cT2) renal masses. Her work, which includes the landmark multicenter ROSULA collaborative study (147 citations), consistently demonstrates that these techniques can preserve renal function without compromising oncologic outcomes. She has also explored the role of regional anesthesia, such as the transversus abdominis plane block, to improve postoperative recovery. With multiple high-impact publications in top-tier journals and a cumulative citation count exceeding 550, Dr. Costantini’s research has reshaped surgical standards, proving that zero-ischemia robotic partial nephrectomy is both feasible and safe for a broad spectrum of patients.
Research Focus
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Top Papers
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