Leonard Moise
Papers
2
Total Citations
28
H-Index
2
About
Leonard Moise is a researcher specializing in immunology and epitope biology, with a particular focus on MHC II binding assays and the identification, deletion, and design of immunogenic peptide epitopes. His work sits at the intersection of biochemical methodology and translational immunology, developing tools that accelerate the characterization of T cell epitopes relevant to vaccine development, autoimmunity, and biotherapeutic deimmunization. Moise's most recognized contribution is the development and optimization of a high-throughput MHC II binding assay scaled to 384-well format, published in 2014 and accumulating nearly 30 citations across related iterations. This methodological advancement significantly reduced reagent costs by 75% while increasing assay efficiency, making quantitative epitope analysis more accessible to the broader research community. By enabling rapid screening of peptide-MHC II interactions using recombinant human molecules, his platform has provided researchers with a practical and cost-effective tool for mapping immunogenic regions in proteins of therapeutic or vaccine interest. Moise's contributions reflect a commitment to bridging technical innovation with applied immunological research, providing the scientific community with scalable, reproducible methods that support both basic science discovery and the rational engineering of safer, more effective biologics and vaccines.
Research Focus
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Top Papers
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