Kimberly M. Romero

Papers

Total Citations

421

H-Index

About

Kimberly M. Romero is a leading immunologist whose work has transformed how we study the humoral immune response to infectious diseases. Her most influential contribution is the development of a high-throughput PCR recombination cloning and expression platform, which enables the creation of complete proteome microarrays. This breakthrough, detailed in her landmark 2005 paper (421 citations), directly addressed a critical bottleneck in pathogen research: the inability to efficiently produce entire proteomes from sequenced genomes. By allowing hundreds of genes to be batch-processed and screened simultaneously, Romero’s platform accelerated the discovery of vaccine and diagnostic antigens, providing a powerful tool for profiling immune responses at an unprecedented scale. Her work has been instrumental in advancing high-throughput serological studies, enabling researchers to rapidly identify immunogenic proteins from a wide range of human pathogens. This innovation not only deepened our understanding of host-pathogen interactions but also streamlined the path from genomic data to practical applications in vaccine development and infectious disease diagnostics. Romero’s contributions remain a cornerstone of modern proteomics and immunology.