Kim Lewis
Papers
1
Total Citations
210
H-Index
1
About
Kim Lewis is a pioneering microbiologist whose research has fundamentally reshaped the search for new antibiotics. His key contributions center on uncovering the mechanisms of bacterial persistence and developing innovative strategies to combat multidrug-resistant pathogens. Lewis is best known for his groundbreaking work on persister cells—dormant bacterial variants that survive antibiotic treatment without genetic resistance—and for championing the use of novel screening platforms to discover antimicrobials. His highly cited 2009 study, which introduced a high-throughput whole animal infection model using *Caenorhabditis elegans*, revolutionized the field by enabling the identification of compounds with *in vivo* anti-infective properties against human pathogens like *Enterococcus faecalis*. This work, garnering over 210 citations, exemplifies his approach of bypassing traditional *in vitro* screens to find drugs that work in living systems. Lewis’s impact is profound: his research has opened new avenues for targeting dormant bacteria, a major cause of chronic infections, and has inspired a generation of scientists to rethink antibiotic discovery. His achievements include numerous awards and a lasting legacy in the fight against antimicrobial resistance.
Research Focus
Key Achievements
Top Papers
- 1