Kevin L. Facchine
Papers
1
Total Citations
36
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1
About
Kevin L. Facchine is a distinguished analytical chemist whose work has significantly advanced the safety and quality control of pharmaceutical manufacturing. His primary research focuses on the development and validation of robust analytical methods for detecting and quantifying genotoxic impurities, a critical area for ensuring patient safety. Facchine’s most notable contribution is his landmark study on the formation of ethyl methane sulfonate (EMS) from ethanol and methane sulfonic acid, where he pioneered an automated static headspace gas chromatography–mass spectrometry (SHS-GC–MS) method. This work, cited 36 times, provided the pharmaceutical industry with a reliable, high-throughput tool to monitor this hazardous reaction, directly addressing a major regulatory concern. By enabling precise detection of trace-level impurities, Facchine’s method has become a cornerstone for process control in drug synthesis, helping manufacturers prevent contamination and comply with stringent international guidelines. His research exemplifies the critical intersection of analytical innovation and public health, making him a key figure in the field of pharmaceutical impurity analysis.
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