Keith W. VanDusen
Papers
1
Total Citations
43
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1
About
Keith W. VanDusen is a biomedical researcher whose work centers on skeletal muscle tissue engineering and regenerative medicine, with a particular focus on improving the functional performance of engineered muscle constructs. His major contributions include pioneering the use of dexamethasone to enhance the maturation and force production of tissue-engineered skeletal muscle units, demonstrating that this glucocorticoid can significantly increase myotube diameter and contractile strength. His most cited paper, "Effects of Dexamethasone on Satellite Cells and Tissue Engineered Skeletal Muscle Units" (2016, 43 citations), addresses a critical bottleneck in the field: the inability of engineered muscle to generate forces comparable to native tissue. By systematically investigating how dexamethasone influences satellite cell behavior and myofiber development, VanDusen provided a foundational strategy for creating more robust muscle grafts. This work has implications not only for repairing soft tissue injuries but also for developing pharmaceutical testing platforms and biomechanical actuators for soft robotics. His research bridges basic cell biology with translational applications, offering a pathway toward clinically viable muscle replacements.
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