Kathleen E. Franks-Skiba
Papers
1
Total Citations
17
H-Index
1
About
Kathleen E. Franks-Skiba is a geneticist whose work has advanced our understanding of complex genetic interactions, particularly through quantitative analysis of multi-gene systems. Her most-cited paper, "Quantitative analysis of triple-mutant genetic interactions" (2014, 17 citations), provides a foundational framework for dissecting how three or more mutations interact to influence phenotypes—a critical step beyond traditional pairwise studies. This work has implications for unraveling the genetic architecture of diseases and developmental processes, where multiple genes often act in concert. Franks-Skiba’s research sits at the intersection of systems biology and functional genomics, employing rigorous statistical and experimental approaches to map genetic networks. While her citation count reflects a niche but impactful contribution, her methodological innovations have been instrumental for researchers exploring epistasis and genetic buffering. By enabling more precise predictions of how genetic perturbations combine, her findings support both basic biological discovery and translational applications, such as identifying combinatorial drug targets. Franks-Skiba’s dedication to quantitative genetics continues to inspire deeper inquiry into the hidden complexity of the genome.
Research Focus
Key Achievements
Top Papers
- 1Quantitative analysis of triple-mutant genetic interactions17 citations · 2014