Kamran Haider
Papers
1
Total Citations
31
H-Index
1
About
Kamran Haider is a structural biologist whose work illuminates how nature degrades synthetic pollutants at the atomic level. His research centers on the structural and mechanistic characterization of unusual cytochrome P450 enzymes, with a particular focus on bioremediation and explosive degradation. Haider’s landmark contribution is the 1.5-Å crystal structure of XplA-heme, the catalytic domain of a remarkable cytochrome P450 from *Rhodococcus* that breaks down the military explosive RDX—a recalcitrant environmental pollutant. This structure, published in a high-impact study with over 31 citations, revealed a unique heme domain architecture that is C-terminally fused to its own flavodoxin redox partner, a rare arrangement that enables efficient electron transfer for reductive catalysis. By solving this structure, Haider provided the molecular blueprint for understanding how XplA, together with its reductase XplB, catalyzes the breakdown of nitramine explosives—a critical step toward developing bioremediation strategies for contaminated military sites. His work stands as a foundational contribution to the field of environmental enzymology, demonstrating how structural insights can guide the engineering of enzymes for pollutant degradation.
Research Focus
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Top Papers
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