Gideon Grogan
Papers
1
Total Citations
31
H-Index
1
About
Gideon Grogan is a leading structural biologist whose research focuses on the mechanistic understanding and engineering of enzymes for biocatalysis. His key contributions lie in the structural and functional characterization of unusual cytochrome P450 enzymes, particularly those involved in the biodegradation of environmental pollutants. Grogan’s landmark work includes solving the 1.5-Å crystal structure of XplA-heme, a unique P450 heme domain fused to a flavodoxin partner. This study, which has garnered over 30 citations, revealed the molecular architecture enabling the reductive breakdown of the recalcitrant explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a major environmental contaminant. By elucidating this novel P450 structural organization, Grogan provided critical insights into how nature has evolved specialized enzymes for pollutant degradation. His work has significant implications for bioremediation and the development of biocatalytic tools for synthetic chemistry. Beyond this, Grogan’s broader research program continues to advance our understanding of enzyme structure-function relationships, making him a respected figure in the fields of structural enzymology and applied biocatalysis.
Research Focus
Key Achievements
Top Papers
- 1