John A. McLean

Papers

Total Citations

H-Index

About

John A. McLean is a leading figure in analytical chemistry and metabolomics, renowned for pioneering the integration of ion mobility spectrometry with mass spectrometry (IM-MS) for high-throughput biological analysis. His major contributions center on developing automated, data-rich platforms that transform complex metabolomic and lipidomic datasets into actionable biological insights. McLean’s work on "AutonoMS" exemplifies his drive to replace labor-intensive manual workflows with robotic, AI-guided systems, dramatically increasing reproducibility and throughput in molecular fingerprinting. With over 150 publications and more than 10,000 citations, his innovations have been instrumental in advancing structural biology and precision medicine. Notably, his development of drift-tube IM-MS methods has enabled the rapid separation of isomers and conformers, a feat critical for understanding disease mechanisms. McLean’s research has earned him accolades such as the ACS Award in Chromatography, and his automated metabolomic platforms are now used globally to accelerate biomarker discovery and drug development. For students and researchers, his work represents the cutting edge of how automation and analytical chemistry converge to solve grand challenges in health and disease.