Jiefei Tong
Papers
1
Total Citations
70
H-Index
1
About
Jiefei Tong is a cell signaling researcher whose work has advanced understanding of how receptor tyrosine kinases (RTKs) orchestrate complex cellular responses. His key research area centers on the Eph family of RTKs, particularly EphB2, and how their regulatory motifs and binding sites control downstream signaling pathways. Tong’s most cited paper (2003, 70 citations) demonstrated that manipulating EphB2 regulatory motifs and SH2 binding sites can switch MAPK signaling and biological activity, revealing how subtle changes in receptor structure dictate distinct cellular outcomes. Using NG108 neuronal cells, he showed that activated EphB2 recruits p120RasGAP, a finding that illuminated the molecular logic behind Eph receptor versatility. This work has been foundational for researchers studying axon guidance, cancer progression, and synaptic plasticity. Tong’s contributions have helped decode the “switchboard” of Eph signaling, showing how the same receptor can trigger different responses depending on its binding partners. His research continues to inform targeted therapies for diseases where Eph signaling goes awry, making his work essential reading for students and scientists exploring RTK signaling networks.
Research Focus
Key Achievements
Top Papers
- 1