Hajime Mizukami

Tokyo University of Agriculture and Technology

Papers

Total Citations

H-Index

About

Hajime Mizukami is a developmental biologist whose research centers on single-cell manipulation and gene expression control in embryonic stem cells. His most notable contribution is the development of a high-performance microinjection technique for semi-quantitative expression and knockdown of target genes in single-cell mouse embryonic stem cells, as detailed in his 2006 paper (15 citations). This work provided a precise tool for studying gene function at the single-cell level, enabling researchers to analyze how specific genes influence cell fate decisions during early development. Mizukami’s approach bridged the gap between bulk population studies and single-cell resolution, offering a method to achieve controlled, reproducible genetic perturbations in individual cells. While his citation count reflects a focused niche, his technical innovation has been instrumental for labs investigating stem cell pluripotency and differentiation. His work underscores the importance of microinjection as a versatile technique for functional genomics, and his contributions continue to inform methodologies in developmental biology and regenerative medicine.