Garib N. Murshudov

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About

Garib N. Murshudov is a leading figure in structural biology, renowned for his transformative contributions to macromolecular crystallography. His research centers on the development of computational methods for protein structure determination, with a particular focus on molecular replacement and refinement. Murshudov is the principal architect of the widely used REFMAC5 software, which has become an essential tool for refining crystallographic models against experimental data. His work on automated molecular replacement, notably the development of the MrBUMP pipeline, has dramatically streamlined the process of solving novel protein structures, enabling high-throughput structural biology. With over 30,000 citations across his body of work, his impact is profound; his seminal paper on refinement of macromolecular structures alone has garnered more than 12,000 citations. A key achievement includes his role in advancing maximum-likelihood-based refinement, which has set the standard for accuracy in model building. Murshudov’s methods underpin countless discoveries in drug design and enzymology, making him an indispensable figure in the field.