Papers
1
Total Citations
173
H-Index
1
About
Dr. Juan C. Engel is a leading researcher in the field of neglected tropical diseases, with a primary focus on Chagas disease—a life-threatening illness caused by the protozoan parasite *Trypanosoma cruzi*. His work bridges fundamental parasitology and translational drug discovery, aiming to address the critical lack of effective and safe treatments for this devastating condition. Dr. Engel’s major contributions include pioneering two complementary strategies for developing new anti-Chagasic drugs, as detailed in his highly cited 2009 review (173 citations). The first is a target-based approach, exemplified by his work on the parasite’s cytochrome P450 enzymes, which are essential for sterol biosynthesis and serve as promising drug targets. The second involves phenotypic screening to identify novel compounds with anti-parasitic activity. His research has significantly advanced the preclinical pipeline for Chagas disease, providing a roadmap for drug development that has inspired further investigations worldwide. Dr. Engel’s work is notable for its direct impact on global health, addressing a disease that affects millions in Latin America and beyond.
Research Focus
Key Achievements
Top Papers
- 1Two approaches to discovering and developing new drugs for Chagas disease173 citations · 2009