E. Brian Butler

Baylor College of Medicine, Houston Methodist

Papers

Total Citations

386

H-Index

About

E. Brian Butler is a distinguished researcher whose work bridges oncology and proteomics, with a primary focus on cancer biomarker discovery and renal cell carcinoma. His most impactful contribution came in 2003 with the development of a practical antibody microarray strategy for serum protein profiling, applied to identify potential biomarkers in prostate cancer. This seminal paper, which has garnered 384 citations, demonstrated a novel approach to comparing protein abundances between cancer and control serum samples, paving the way for non-invasive diagnostic tools. Butler’s methodology enabled the screening of 33 prostate cancer sera against 20 controls, establishing a reproducible framework for biomarker validation. His later work includes a comprehensive overview of renal cell carcinoma, reflecting his sustained interest in urological malignancies. Through his innovative use of antibody microarrays, Butler has advanced the field of cancer proteomics, offering researchers a powerful tool for early detection and personalized medicine. His contributions continue to influence studies on serum-based diagnostics and cancer biology.