Charles K. Marlowe
Papers
1
Total Citations
939
H-Index
1
About
Charles K. Marlowe pioneered the field of peptoid-based drug discovery, fundamentally reshaping how researchers approach molecular diversity and therapeutic design. His landmark 1992 paper, "Peptoids: a modular approach to drug discovery," has garnered nearly 1,000 citations, cementing its status as a foundational work in chemical biology. Marlowe introduced peptoids—oligomers of N-substituted glycines—as a versatile, modular scaffold for generating chemically diverse libraries. By calculating Ramachandran-type plots, he demonstrated that peptoids access a far greater range of conformational states than traditional peptides, unlocking new possibilities for drug development. This breakthrough not only expanded the toolkit for medicinal chemists but also laid the groundwork for peptoid-based therapeutics with enhanced stability and bioavailability. Marlowe's work continues to inspire innovation in combinatorial chemistry and biomimetic design, making him a pivotal figure in the quest for next-generation pharmaceuticals.
Research Focus
Key Achievements
Top Papers
- 1Peptoids: a modular approach to drug discovery.939 citations · 1992