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About

Bret Nestor is a pioneering researcher in the field of organ-on-a-chip technology, with a primary focus on developing automated, robotic platforms for multi-organ physiological modeling. His major contributions center on creating "body-on-chips" systems that fluidically link multiple vascularized organ chips to mimic human systemic physiology. Nestor’s most impactful work, "Robotic fluidic coupling and interrogation of multiple vascularized organ chips" (2020, 401 citations), introduced a revolutionary approach to automate the culture, perfusion, and real-time imaging of interconnected organ models. He also co-developed the "Interrogator" platform, a robotic instrument capable of managing up to 10 Organ Chips simultaneously, enabling automated medium exchange, fluidic linking, and in situ microscopy. This work has significantly advanced the scalability and reproducibility of organ-chip experiments, reducing manual handling and opening new avenues for drug testing and disease modeling. Nestor’s achievements have established him as a key innovator in the transition from single-organ to multi-organ chip systems, with his highly cited 2020 paper reflecting the field’s recognition of his contributions to automated, high-throughput physiological modeling.