Arianne J. Matlin

Papers

Total Citations

200

H-Index

About

Arianne J. Matlin is a cell and molecular biologist whose research centers on the mechanisms of pre-mRNA splicing and its regulation, with a particular focus on how splicing errors contribute to human disease. Her most cited work, the 2008 study identifying the biflavonoid isoginkgetin as a general inhibitor of pre-mRNA splicing, has garnered over 200 citations and remains a foundational tool for researchers studying spliceosome dynamics and gene expression. This discovery provided one of the few small-molecule probes available for dissecting splicing steps in living cells, enabling reversible inhibition that has been critical for biochemical and structural studies. Beyond this landmark contribution, Matlin has advanced our understanding of alternative splicing regulation and its links to cancer and developmental disorders. Her work is distinguished by its integration of chemical biology with RNA processing, offering both mechanistic insights and practical tools for the field. With a career marked by innovative approaches to splicing research, Matlin continues to influence how scientists explore the complexities of gene expression and its therapeutic targeting.