Small molecule

An improved method for the in vitro evolution of aptamers and applications in protein detection and purification

Michael Murphy

Citations: 202 • 2003

An efficient rapid system for profiling the cellular activities of molecular libraries

Jonathan S. Melnick, Jeff Janes, Sung Joon Kim, Jim Chang, Daniel G. Sipes, Drew Gunderson, Laura Jarnes, Jason Matzen, Michael Garcia, Tami Hood, Ronak Beigi, Gang Xia, Richard A. Harig, Hayk Asatryan, S. Frank Yan, Yingyao Zhou, Xiang-ju Gu, Alham Saadat, Vicki Zhou, Frederick J. King, Christopher M. Shaw, Andrew I. Su, Robert T. Downs, Nathanael S. Gray, Peter G. Schultz, Markus Warmuth, Jeremy S. Caldwell

Citations: 185 • 2006

Functionalized Magnetic Nanoparticles for Small-Molecule Isolation, Identification, and Quantification

Po‐Chiao Lin, Mei‐Chun Tseng, An-Kai Su, Yu‐Ju Chen, Chun‐Cheng Lin

Citations: 151 • 2007

A one-bead, one-stock solution approach to chemical genetics: part 2

Paul A. Clemons, Angela N. Koehler, Bridget K. Wagner, Timothy G Sprigings, David R. Spring, Randall W. King, Stuart L. Schreiber, Michael A. Foley

Citations: 107 • 2001

A Repurposing Strategy Identifies Novel Synergistic Inhibitors of <i>Plasmodium falciparum</i> Heat Shock Protein 90

Dea Shahinas, Michael N. Liang, Alessandro Datti, Dylan R. Pillai

Citations: 90 • 2010

A Cell-Based, High-Throughput Screen for Small Molecule Regulators of Hepatitis C Virus Replication

Sun Suk Kim, Lee F. Peng, Wenyu Lin, Won-Hyeok Choe, Naoya Sakamoto, Stuart L. Schreiber, Raymond T. Chung

Citations: 88 • 2006

Activity-Based DNA-Encoded Library Screening

Wesley G. Cochrane, Marie L. Malone, Vương Đặng Quốc, V. Cavett, Alexander L. Satz, Brian M. Paegel

Citations: 85 • 2019

Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay

N.C. Gassner, Craig M. Tamble, Jonathan Bock, Naomi Cotton, Kimberly N. White, Karen Tenney, Robert P. St.Onge, Michael Proctor, Guri Giaever, Corey Nislow, Ronald W. Davis, Phillip Crews, Theodore R. Holman, R. Scott Lokey

Citations: 57 • 2007

Using Exonucleases for Aptamer Characterization, Engineering, and Sensing

Obtin Alkhamis, Juan Canoura, Phuong T. Ly, Yi Xiao

Citations: 53 • 2023

Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach

Wei Chen, Minyong Chen, Larry S. Barak

Citations: 51 • 2010

ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates

David T. White, Arife Unal Eroglu, Guohua Wang, Liyun Zhang, S. Sengupta, Ding Ding, Surendra K. Rajpurohit, Steven L. Walker, Hongkai Ji, Jiang Qian, Jeff S. Mumm

Citations: 50 • 2016

Streamlining bioactive molecular discovery through integration and automation

Shiao Y. Chow, Samuel Liver, Adam Nelson

Citations: 50 • 2018

Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research

Dean G. Brown, Heike J. Wobst

Citations: 49 • 2019

Automated stereocontrolled assembly-line synthesis of organic molecules

Valerio Fasano, Rory C. Mykura, James M. Fordham, Jack Rogers, Borys Banecki, Adam Noble, Varinder K. Aggarwal

Citations: 46 • 2022

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Lakshmi Prabhu, Lan Chen, Wei Han, Özlem Demir, Ahmad R. Safa, Li‐Fan Zeng, Rommie E. Amaro, Bert H. O’Neil, Zhon-Yin Zhang, Tao Lu

Citations: 39 • 2017

Stimuli‐Responsive Materials from Ferrocene‐Based Organic Small Molecule for Wearable Sensors

Ling Li, Jianyu Zhang, Chenyi Yang, Le Huang, Jun Zhang, Jie Bai, Carl Redshaw, Xing Feng, Changyong Cao, Nengjie Huo, Jingbo Li, Ben Zhong Tang

Citations: 31 • 2021

The Microphenotron: a robotic miniaturized plant phenotyping platform with diverse applications in chemical biology

Thomas Burrell, Susan Fozard, Geoff H. Holroyd, Andrew P. French, Michael P. Pound, Christopher Bigley, C. James Taylor, Brian Forde

Citations: 31 • 2017

Integrated System Built for Small-Molecule Semiconductors via High-Throughput Approaches

Jianchang Wu, Jiyun Zhang, Manman Hu, Patrick Reiser, Luca Torresi, Pascal Friederich, Leopold Lahn, Olga Kasian, Dirk M. Guldi, M. Eugenia Pérez‐Ojeda, Anastasia Barabash, Juan S. Rocha‐Ortiz, Yicheng Zhao, Zhiqiang Xie, Junsheng Luo, Yunuo Wang, Sang Il Seok, Jens Hauch, Christoph J. Brabec

Citations: 29 • 2023

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha

Nivedita Sengupta, Marko Jović, Elena Barnaeva, David W. Kim, Xin Hu, Noel Southall, Milan Dejmek, Ivana Mejdrová, Radim Nencka, Adriana Bäumlová, Dominika Chalupská, Evžen Bouřa, Marc Ferrer, Juan Marugán, Tamás Balla

Citations: 28 • 2019

High-Throughput Small Molecule Identification Using MALDI-TOF and a Nanolayered Substrate

Jeong Heon Lee, Hak Soo Choi, Khaled Nasr, Mi-Young Ha, Yangsun Kim, John V. Frangioni

Citations: 25 • 2011