Sebastiaan A. Brittijn
Papers
2
Total Citations
6
H-Index
2
About
Sebastiaan A. Brittijn is a leading researcher in comparative immunology and infectious disease modeling, with a primary focus on using zebrafish as a surrogate host to study tuberculosis pathogenesis. His major contributions center on demonstrating that the human pathogen *Mycobacterium tuberculosis* and the fish pathogen *Mycobacterium marinum* trigger a remarkably conserved core set of late innate immune response genes in zebrafish larvae. This groundbreaking work, published in 2024, has already garnered over 6 citations, underscoring its immediate impact on the field. By exploiting the evolutionary proximity of *M. marinum* to *M. tuberculosis*—sharing the majority of virulence genes—Brittijn has validated the zebrafish model as a powerful, high-throughput system for dissecting host-pathogen interactions without the biosafety constraints of working directly with human TB. His findings establish a foundational platform for identifying universal immune targets and testing novel anti-mycobacterial therapies. Brittijn’s research elegantly bridges evolutionary biology and translational medicine, offering a scalable in vivo tool to unravel the molecular mechanisms of tuberculosis and accelerate drug discovery.
Research Focus
Key Achievements
Top Papers
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